{"id":251847,"date":"2025-07-22T14:01:08","date_gmt":"2025-07-22T13:01:08","guid":{"rendered":"https:\/\/purovitalis.com\/?p=251847"},"modified":"2026-05-18T09:58:43","modified_gmt":"2026-05-18T07:58:43","slug":"autophagy","status":"publish","type":"post","link":"https:\/\/staging.purovitalis.com\/es\/autophagy\/","title":{"rendered":"Autofagia y limpieza celular: La ciencia de la autorrenovaci\u00f3n, la senescencia y la longevidad"},"content":{"rendered":"<div class=\"taxonomy-post_tag blog-tags wp-block-post-terms\"><a href=\"https:\/\/staging.purovitalis.com\/es\/tag\/longevity\/\" rel=\"tag\">longevity<\/a><\/div>\n\n\n<div class=\"wp-block-group blog-table-of-contents is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">table of contents<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#h-what-is-autophagy\">What is autophagy?<\/a><\/li>\n\n\n\n<li><a href=\"#h-autophagy-benefits-why-cellular-clean-up-matters\">Autophagy benefits: Why cellular clean-up matters<\/a><\/li>\n\n\n\n<li><a href=\"#h-fasting-and-autophagy-how-skipping-meals-cleans-your-cells\">Fasting and autophagy: How skipping meals cleans your cells<\/a><\/li>\n\n\n\n<li><a href=\"#h-when-does-autophagy-start\">When does autophagy start?<\/a><\/li>\n\n\n\n<li><a href=\"#h-autophagy-and-senescence-a-complex-relationship\">Autophagy and senescence: A complex relationship<\/a><\/li>\n\n\n\n<li><a href=\"#h-can-senescent-cells-be-cleaned-up-or-repaired-by-autophagy\">Can senescent cells be cleaned up or repaired by autophagy?<\/a><\/li>\n\n\n\n<li><a href=\"#h-what-promotes-autophagy-lifestyle-factors-and-more\">What promotes autophagy? Lifestyle factors and more<\/a><\/li>\n\n\n\n<li><a href=\"#h-autophagy-and-longevity-the-science\">Autophagy and longevity: The science<\/a><\/li>\n\n\n\n<li><a href=\"#h-faqs-on-autophagy\">FAQs on autophagy <\/a><br><\/li>\n<\/ul>\n<\/div>\n\n\n\n<figure class=\"wp-block-pullquote blog-quote blog-quote-line\"><blockquote><p>\u201caw-TAH-fuh-jee\u201d<\/p><cite>pronunciation<\/cite><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-autophagy\">What is autophagy? <\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Autophagy is your body\u2019s built-in cellular clean-up crew. It\u2019s a natural process where cells break down and recycle their own damaged parts\u2014think of it as spring cleaning at the microscopic level. This process is essential for maintaining cellular health, removing dysfunctional proteins and organelles, and ensuring your cells run efficiently. During autophagy, cells form special structures called autophagosomes that engulf unwanted cellular debris, which are then broken down and recycled for energy or to build new cellular components. This self-renewal is vital for health, longevity, and disease prevention[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18305538\/\" rel=\"nofollow noopener\" target=\"_blank\">1<\/a>].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-autophagy-benefits-why-cellular-clean-up-matters\">Autophagy benefits: Why cellular clean-up matters<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Benefit<\/strong><\/th><th><strong>Effect<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>Cellular Rejuvenation<\/strong><\/td><td>By removing damaged parts, autophagy helps cells function better and live longer.<\/td><\/tr><tr><td><strong>Disease Prevention<\/strong><\/td><td>Autophagy protects against neurodegenerative diseases and infections.<\/td><\/tr><tr><td><strong>Longevity<\/strong><\/td><td>Studies in animals show that increased autophagy is linked to longer lifespans and healthier aging.<\/td><\/tr><tr><td><strong>Metabolic Health<\/strong><\/td><td>Autophagy supports healthy metabolism and may help prevent obesity and diabetes.[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2990190\/\" rel=\"nofollow noopener\" target=\"_blank\">2<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18191218\/\" rel=\"nofollow noopener\" target=\"_blank\">3<\/a>]<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-fasting-and-autophagy-how-skipping-meals-cleans-your-cells\">Fasting and autophagy: How skipping meals cleans your cells<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most powerful ways to trigger autophagy is through fasting. When you fast, your body senses a lack of nutrients and activates autophagy to recycle internal resources for energy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This shift usually happens once glycogen stores in the liver are depleted and the body begins to rely more on fat for fuel. In this energy-conserving mode, cells ramp up internal clean-up to remove damaged components and repurpose them\u2014essentially turning waste into fuel and repair material.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Different fasting methods like time-restricted eating (as for example the 16:8 fasting method), alternate-day fasting, or periodic 24\u201348 hour fasts as well as 72 hour three-day fasts (done not too often) can all stimulate autophagy to varying degrees, depending on individual metabolism, activity level, and overall health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Not only does this support cellular health, but it may also reduce inflammation, improve insulin sensitivity, and contribute to longevity through better cellular resilience[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30172870\/\" rel=\"nofollow noopener\" target=\"_blank\">4<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31881139\/\" rel=\"nofollow noopener\" target=\"_blank\">5<\/a>].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-when-does-autophagy-start\">When does autophagy start?<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Hours fasted<\/strong><\/th><th><strong>Autophagy activity<\/strong><\/th><\/tr><\/thead><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>0\u201312<\/td><td>Baseline (low)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>12\u201316<\/td><td>Begins to increase<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>16\u201324<\/td><td>Moderate activation<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>24\u201348<\/td><td>Peak activation<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>48+<\/td><td>May plateau or decline<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\"><em>Note: Individual responses vary. Always consult a healthcare professional before extended fasting.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Autophagy doesn\u2019t switch on instantly when you skip a meal. Research suggests that autophagy begins to ramp up after about 12\u201316 hours of fasting, with peak activity often occurring between 24\u201348 hours, depending on individual metabolism and activity levels[<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1905136\" rel=\"nofollow noopener\" target=\"_blank\">6<\/a>].<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-does-lemon-water-break-autophagy\">Does lemon water break autophagy?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A common question is whether lemon water breaks autophagy. The answer: plain lemon water (without sugar or calories) is unlikely to significantly disrupt autophagy, as the process is mainly sensitive to caloric intake. However, adding sugar or honey would provide energy and could reduce autophagic activity, so if you want to list foods that support autophagy, nothing with calories will work.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-autophagy-vs-apoptosis-what-s-the-difference\">Autophagy vs apoptosis: What\u2019s the difference?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Both are essential for health, but autophagy is about repair and renewal, while apoptosis is about removal.Together, they play a key role in maintaining cellular balance and supporting longevity[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21760595\/\" rel=\"nofollow noopener\" target=\"_blank\">11<\/a>,<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24401948\/\" rel=\"nofollow noopener\" target=\"_blank\">12<\/a>].<\/p>\n\n\n\n<div class=\"wp-block-group blog-definition is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">Definition Autophagy<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Autophagy is the process of cleaning and recycling parts within a living cell\u2014think of it as maintenance.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group blog-definition is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">Definition Apoptosis<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Apoptosis is programmed cell death, where the entire cell is dismantled and removed when it\u2019s no longer needed or is damaged beyond repair.<\/p>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-senescent-cells-can-autophagy-clean-up-or-repair-them\">Senescent cells: Can autophagy clean up or repair them?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cellular senescence is a state where cells stop dividing and enter a permanent arrest, often as a response to stress, DNA damage, or aging. Senescent cells accumulate with age and contribute to tissue dysfunction, chronic inflammation, and age-related diseases. They are characterized by the secretion of inflammatory factors known as the senescence-associated secretory phenotype  &#8211; SASP.<\/p>\n\n\n\n<div class=\"wp-block-group blog-definition is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">What is SASP? <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SASP (<em>senescence-associated secretory phenotype<\/em>) refers to the substances released by senescent cells, including inflammatory signals and proteins. These can damage surrounding tissue and contribute to chronic inflammation and age-related diseases.<\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-autophagy-and-senescence-a-complex-relationship\">Autophagy and senescence: A complex relationship<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Autophagy and cellular senescence are intimately linked. Autophagy can both suppress and promote senescence, depending on the context:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Anti-senescence role:<\/em> <br>Autophagy helps prevent the onset of senescence by removing damaged proteins and organelles, maintaining cellular homeostasis. In muscle stem cells, for example, basal autophagy is essential to keep cells in a healthy, quiescent state and prevent them from becoming senescent. When autophagy is impaired, these cells accumulate damage and enter senescence. Remarkably, restoring autophagy in aged stem cells can reverse senescence and rejuvenate their regenerative capacity. Read on to learn how long do you need to fast for stem cell regeneration.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pro-senescence role:<\/em> <br>In some contexts, autophagy can facilitate the establishment of senescence, particularly by supporting the synthesis of SASP factors. For instance, during oncogene-induced senescence, autophagy provides the building blocks for the production of SASP proteins, reinforcing the senescent state.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Cell fate decisions:<\/em> <br>The interplay between autophagy, senescence, and apoptosis is regulated by stress signaling pathways such as p38\u03b1. P38\u03b1 is a type of protein kinase\u2014a signaling molecule inside cells that helps control how the cell responds to stress, inflammation, and damage. <\/p>\n\n\n\n<div class=\"wp-block-group blog-summary is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">In short <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Autophagy and cellular aging are closely connected. Autophagy can help prevent cells from becoming senescent (old and inactive), but in some cases, it can also support the senescent state. When autophagy works well, it keeps cells healthy and youthful. <\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-can-senescent-cells-be-cleaned-up-or-repaired-by-autophagy\">Can senescent cells be cleaned up or repaired by autophagy?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Prevention and reversal: <\/em><br>Autophagy is most effective at preventing cells from becoming senescent in the first place. In some cases, reactivating autophagy in aged or damaged stem cells can reverse senescence and restore function.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Clearance: <\/em><br>While autophagy can help maintain tissue health by preventing the accumulation of senescent cells, the actual removal of established senescent cells often requires immune system involvement or targeted therapies (senolytics). However, enhancing autophagy may reduce the burden of senescent cells indirectly by improving overall cellular quality control.<\/p>\n\n\n\n<div class=\"wp-block-group blog-definition is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">What are Senolytics? <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Senolytics are compounds that help remove senescent cells. By clearing these cells, senolytics may reduce chronic inflammation, improve tissue health, and support healthy aging. Early research shows promise for age-related diseases like heart disease and dementia. Examples include natural compounds like <a href=\"https:\/\/staging.purovitalis.com\/products\/liposomal-quercetin\/\">quercetin<\/a>, among others.<\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-promotes-autophagy-lifestyle-factors-and-more\">What promotes autophagy? Lifestyle factors and more<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Intermittent fasting: <\/em><br>The most effective non-genetic trigger for autophagy. Try 16:8 or 24-hour fasts for optimal results.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Exercise: <\/em><br>Physical activity, especially aerobic exercise, stimulates autophagy in muscles and other tissues.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Ketogenic diet: <\/em><br>Low-carb, high-fat diets mimic fasting and can promote autophagy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Caloric restriction: <\/em><br>Eating fewer calories without malnutrition is a proven way to boost autophagy and extend lifespan in animal studies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Certain compounds: <\/em><br>Substances like curcumin (from turmeric) and <a href=\"https:\/\/staging.purovitalis.com\/products\/liposomal-resveratrol\/\">resveratrol<\/a> may also enhance autophagy, though more research is needed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-autophagy-and-longevity-the-science\">Autophagy and longevity: The science<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Recent studies show that autophagy is not just associated with, but necessary for, healthy aging and lifespan extension. In animal models, boosting autophagy leads to longer, healthier lives, while blocking it accelerates aging and disease. Intermittent fasting, which increases autophagy, is linked to reduced inflammation, improved metabolic health, and greater longevity. [22, 23]For a deep dive into how fasting supports healthy aging, check out our guide: <a href=\"https:\/\/staging.purovitalis.com\/effects-of-intermittent-fasting-on-healthy-ageing-the-complete-guide\/\">Effects of intermittent fasting: Health and aging guide<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-faqs-on-autophagy\">FAQs on autophagy <\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Question<\/strong><\/th><th><strong>Answer<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>What is autophagy?<\/strong><\/td><td>Autophagy is the body\u2019s way of cleaning out damaged cells and recycling their parts for new use.<\/td><\/tr><tr><td><strong>How do you pronounce autophagy?<\/strong><\/td><td>aw-TAH-fuh-jee.<\/td><\/tr><tr><td><strong>When does autophagy start during fasting?<\/strong><\/td><td>Typically after 12\u201316 hours of fasting, with peak activity at 24\u201348 hours.<\/td><\/tr><tr><td><strong>Does lemon water break autophagy?<\/strong><\/td><td>No, plain lemon water without calories is unlikely to break autophagy.<\/td><\/tr><tr><td><strong>What\u2019s the difference between autophagy and apoptosis?<\/strong><\/td><td>Autophagy is cellular clean-up; apoptosis is programmed cell death.<\/td><\/tr><tr><td><strong>Can autophagy clean up senescent cells?<\/strong><\/td><td>Autophagy can prevent and sometimes reverse senescence in certain cell types, especially stem cells, but established senescent cells are usually cleared by the immune system or targeted therapies. Enhancing autophagy supports overall cellular health and may reduce the accumulation of senescent cells.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Explore more here: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/staging.purovitalis.com\/effects-of-intermittent-fasting-on-healthy-ageing-the-complete-guide\/\"><em>Effects of intermittent fasting: Health and aging guide<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/staging.purovitalis.com\/caffeine-and-intermittent-fasting-a-cheat-or-a-hack\/\"><em>Caffeine and intermittent fasting: A cheat or a hack?<\/em><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/staging.purovitalis.com\/understand-mitophagy-your-bodys-defense-against-aging\/\"><em>Understand Mitophagy: Your Body\u2019s Defense Against Aging<\/em><\/a><\/li>\n<\/ul>\n\n\n\n<details class=\"wp-block-details blog-references is-layout-flow wp-block-details-is-layout-flow\"><summary>References <\/summary>\n<ol class=\"wp-block-list\">\n<li>Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. <em>Nature<\/em>. 2008;451(7182):1069\u201375.<\/li>\n\n\n\n<li>Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. <em>J Pathol<\/em>. 2010;221(1):3\u201312.<\/li>\n\n\n\n<li>Levine B, Kroemer G. Autophagy in the pathogenesis of disease. <em>Cell<\/em>. 2008;132(1):27\u201342.<\/li>\n\n\n\n<li>Bagherniya M, Butler AE, Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: A review of the literature. <em>Ageing Res Rev<\/em>. 2018;47:183\u201397.<\/li>\n\n\n\n<li>de Cabo R, Mattson MP. Effects of intermittent fasting on health, aging, and disease. <em>N Engl J Med<\/em>. 2019;381(26):2541\u201351.<\/li>\n\n\n\n<li>Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. <em>Autophagy<\/em>. 2010;6(6):702\u201310.<\/li>\n\n\n\n<li>Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. <em>Ageing Res Rev<\/em>. 2017;39:46\u201358.<\/li>\n\n\n\n<li>Martinez-Lopez N, Tarabra E, Toledo M, Garcia-Macia M, Sahu S, Coletto L, et al. System-wide benefits of intermeal fasting by autophagy. <em>Cell Metab<\/em>. 2017;26(6):856\u201371.<\/li>\n\n\n\n<li>Gudden J, Arias Vasquez A, Bloemendaal M. The effects of intermittent fasting on brain and cognitive function. <em>Nutrients<\/em>. 2021;13(9):3166.<\/li>\n\n\n\n<li>Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting. <em>Obesity (Silver Spring)<\/em>. 2018;26(2):254\u201368.<\/li>\n\n\n\n<li>Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. <em>Cell Death Differ<\/em>. 2012;19(1):107\u201320.<\/li>\n\n\n\n<li>Mari\u00f1o G, Niso-Santano M, Baehrecke EH, Kroemer G. Self-consumption: the interplay of autophagy and apoptosis. <em>Nat Rev Mol Cell Biol<\/em>. 2014;15(2):81\u201394.<\/li>\n\n\n\n<li>Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, et al. Daily fasting improves health and survival in male mice independent of diet composition and calories. <em>Cell Metab<\/em>. 2019;29(1):221\u20138.<\/li>\n\n\n\n<li>Madeo F, Zimmermann A, Maiuri MC, Kroemer G. Essential role for autophagy in life span extension. <em>J Clin Invest<\/em>. 2015;125(1):85\u201393.<\/li>\n\n\n\n<li>Garc\u00eda-Prat L, Mart\u00ednez-Vicente M, Perdiguero E, Ortet L, Rodr\u00edguez-Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. <em>Nature<\/em>. 2016;529(7584):37\u201342.<\/li>\n\n\n\n<li>Nakamura S, Yoshimori T. Autophagy and longevity. <em>Mol Cells<\/em>. 2018;41(1):65\u201372.<\/li>\n\n\n\n<li>Rubinsztein DC, Mari\u00f1o G, Kroemer G. Autophagy and aging. <em>Cell<\/em>. 2011;146(5):682\u201395.<\/li>\n\n\n\n<li>Kang HT, Lee KB, Kim SY, Choi HR, Park SC. Autophagy impairment induces premature senescence in primary human fibroblasts. <em>PLoS One<\/em>. 2011;6(8):e23367.<\/li>\n\n\n\n<li>Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, et al. Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities. <em>Neuron<\/em>. 2017;93(5):1015\u201334.<\/li>\n\n\n\n<li>Fern\u00e1ndez \u00c1F, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, et al. Disruption of the beclin 1\u2013BCL2 autophagy regulatory complex promotes longevity in mice. <em>Nature<\/em>. 2018;558(7708):136\u201340.<\/li>\n\n\n\n<li>Hansen M, Rubinsztein DC, Walker DW. Autophagy as a promoter of longevity: insights from model organisms. <em>Nat Rev Mol Cell Biol<\/em>. 2018;19(9):579\u201393.<\/li>\n<\/ol>\n<\/details>\n","protected":false},"excerpt":{"rendered":"<p>table of contents \u201caw-TAH-fuh-jee\u201d pronunciation What is autophagy? Autophagy is your body\u2019s built-in cellular clean-up crew. It\u2019s a natural process where cells break down and recycle their own damaged parts\u2014think of it as spring cleaning at the microscopic level. This process is essential for maintaining cellular health, removing dysfunctional proteins and organelles, and ensuring your [&hellip;]<\/p>\n","protected":false},"author":11669,"featured_media":251939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"bwfblock_default_font":"","footnotes":""},"categories":[299,305,184,68],"tags":[177],"class_list":["post-251847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-goal-guides","category-cellular-renewal-detox","category-healthy-aging","category-research","tag-longevity"],"_links":{"self":[{"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/posts\/251847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/users\/11669"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/comments?post=251847"}],"version-history":[{"count":5,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/posts\/251847\/revisions"}],"predecessor-version":[{"id":349483,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/posts\/251847\/revisions\/349483"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/media\/251939"}],"wp:attachment":[{"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/media?parent=251847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/categories?post=251847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.purovitalis.com\/es\/wp-json\/wp\/v2\/tags?post=251847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}