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NMN (Nicotinamide Mononucleotide) is gaining recognition for its potential to improve various aspects of health. Especially in middle-aged and elderly individuals. A recent review of multiple scientific human studies offers insights into how NMN supplements can support muscle function, liver health, and insulin sensitivity. NMN human studies have highlighted these significant benefits.
Key highlights
- Improves muscle function: NMN increased walking speed by up to 20%, helping improve mobility in aging adults.
- Boosts liver health: NMN reduced key liver enzyme levels by around 15%, indicating improved liver function.
- Enhances insulin sensitivity: Lower doses of NMN improved insulin resistance by 8-10%, potentially lowering the risk of diabetes.
- Safe for regular use: NMN supplements were found to be safe with no serious side effects reported across studies.
NMN’s potential in supporting muscle and liver health
As we age, our bodies undergo several changes, and one of the most significant is a decline in the levels of NAD+. A crucial molecule that helps with energy production, DNA repair, and maintaining healthy cells. NMN, a precursor to NAD+, has been studied for its ability to boost NAD+ levels and potentially slow down the effects of aging. NMN human studies continue to reveal these promising effects.
Related: Learn more about the NAD+
Researchers reviewed 9 clinical studies, with a total of 412 participants between the ages of 40 and 80, to see how NMN affects muscle function, liver health, and insulin resistance. Here’s what the research found from these human NMN studies:
1. NMN enhances muscle function
One of the standout findings from the studies was how NMN helps improve muscle function. Particularly in walking speed, which is an important measure of mobility.
In the trials, participants who took NMN supplements saw a 10-20% increase in their walking speed. This improvement was particularly strong in participants under 60, with younger middle-aged individuals seeing the greatest benefits. Walking speed may seem like a small thing, but it’s an important factor in staying active and independent as you age.
The research also suggests that higher doses of NMN, such as 900 mg/day, lead to even greater improvements. For anyone looking to maintain or even boost their physical abilities as they age, NMN could be a helpful supplement.
2. NMN supports liver health
Your liver plays a crucial role in detoxifying your body and maintaining metabolic health. As we age, liver function tends to decline, which can lead to a higher risk of liver disease and other health issues.
In the studies, NMN was shown to reduce levels of ALT (alanine aminotransferase) by 15%, a key enzyme that, when elevated, indicates liver strain or damage. This means that NMN could help protect the liver from age-related decline and improve its overall function. While the reduction in AST (aspartate aminotransferase) wasn’t as pronounced, the decrease in ALT is a promising sign for those concerned about liver health.
3. NMN improves insulin sensitivity
As you age, insulin resistance tends to increase, which can lead to conditions like type 2 diabetes. Insulin sensitivity is crucial for keeping blood sugar levels stable and maintaining metabolic health.
In the reviewed studies, NMN was shown to improve insulin sensitivity by 8-10% in participants, particularly in those taking lower doses of around 300 mg/day. This improvement was most noticeable in participants under 60 years of age, but it also benefited older individuals.
This means that NMN may help reduce the risk of developing insulin resistance and diabetes, making it an important supplement for long-term metabolic health according to the latest NMN human studies.
4. Dosage and safety
The studies reviewed covered different dosages of NMN, with 300 mg/day being the most common and 900 mg/day providing stronger results in areas like muscle function. The good news is that NMN was found to be safe at all tested doses, with no serious side effects reported.
For those new to NMN, starting with a moderate dose of 300-600 mg/day may offer a balance of benefits, particularly for insulin sensitivity and liver health. If muscle function and physical performance are the main goals, higher doses of 900 mg/day may be more appropriate.
Related: Are there side effects of NMN?
Final thoughts
NMN shows a lot of promise for middle-aged and older adults who are looking to stay healthy as they age. Whether you’re interested in improving your mobility, supporting liver function, or reducing your risk of insulin resistance, NMN can help in multiple ways. NMN human studies have shown that its ability to raise NAD+ levels in the body seems to be key to its benefits, helping to maintain energy levels, cellular repair, and overall health.
With a proven safety record and results backed by multiple studies, NMN is an excellent choice for anyone looking to boost their health and longevity.
Ready to experience the benefits of NMN?
If you’re interested in improving your muscle strength, liver health, or metabolic function, NMN supplements could be the solution you’re looking for. Backed by science and shown to be safe, that NMN can help you maintain your vitality as you age.
References
1. Wang, J., et al. (2024). Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-Aged and Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Current Pharmaceutical Biotechnology, 1-11.
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