{"id":170,"date":"2022-12-15T08:17:00","date_gmt":"2022-12-15T07:17:00","guid":{"rendered":"https:\/\/purovitalis.com\/index.php\/2023\/05\/03\/fitter-younger-healthier-a-compelling-human-trial-on-nmn-supplementation\/"},"modified":"2025-08-28T11:18:20","modified_gmt":"2025-08-28T10:18:20","slug":"studiu-convingator-pe-oameni-privind-eficacitatea-nmn","status":"publish","type":"post","link":"https:\/\/staging.purovitalis.com\/ro\/compelling-human-trial-on-nmn-efficacy\/","title":{"rendered":"Studiu: Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu NMN la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie"},"content":{"rendered":"<div class=\"taxonomy-post_tag blog-tags wp-block-post-terms\"><a href=\"https:\/\/staging.purovitalis.com\/ro\/tag\/longevity\/\" rel=\"tag\">longevitate<\/a><span class=\"wp-block-post-terms__separator\"> <\/span><a href=\"https:\/\/staging.purovitalis.com\/ro\/tag\/nmn\/\" rel=\"tag\">nmn<\/a><\/div>\n\n\n<div class=\"wp-block-group blog-table-of-contents\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">cuprins<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#h-purpose-of-the-study\">Scopul studiului<\/a><\/li>\n\n\n\n<li><a href=\"#h-how-the-study-was-conducted\">Modul \u00een care a fost realizat studiul<\/a><\/li>\n\n\n\n<li><a href=\"#h-assessments-and-tests-conducted\">Evalu\u0103ri \u0219i teste efectuate<\/a><\/li>\n\n\n\n<li><a href=\"#h-summary-of-clinical-findings\">Rezumatul constat\u0103rilor clinice<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">De peste un deceniu, NMN se afl\u0103 \u00een centrul aten\u021biei comunit\u0103\u021bii \u0219tiin\u021bifice datorit\u0103 rolului s\u0103u \u00een sus\u021binerea produc\u021biei de energie celular\u0103 \u0219i \u00een men\u021binerea nivelurilor de NAD\u207a \u2014 un factor cheie pentru s\u0103n\u0103tatea metabolic\u0103 \u0219i procesul de \u00eemb\u0103tr\u00e2nire.<br>Studiile efectuate pe animale au demonstrat \u00een mod constant efecte promi\u021b\u0103toare: \u00eembun\u0103t\u0103\u021birea rezisten\u021bei, \u00eembun\u0103t\u0103\u021birea func\u021biei mitocondriale \u0219i semne de \u00eencetinire a \u00eemb\u0103tr\u00e2nirii biologice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cu toate acestea, multe dintre afirma\u021biile privind efectele NMN asupra organismului uman s-au bazat p\u00e2n\u0103 \u00een prezent pe date preclinice. Acest lucru a dat na\u0219tere unor critici, \u00een special din cauza lipsei dovezilor clinice privind eficacitatea sa \u0219i \u2014 la fel de important \u2014 siguran\u021ba sa la persoanele s\u0103n\u0103toase.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Se pare c\u0103 aceast\u0103 incertitudine a fost acum clarificat\u0103. Un nou studiu clinic randomizat, controlat cu placebo, a analizat at\u00e2t eficacitatea, c\u00e2t \u0219i siguran\u021ba supliment\u0103rii cu NMN la adul\u021bi s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie \u2014 iar rezultatele ofer\u0103 perspective noi asupra rolului poten\u021bial al acesteia \u00een s\u0103n\u0103tatea uman\u0103, energia \u0219i longevitatea.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-purpose-of-the-study\">Scopul studiului<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cercet\u0103tori din SUA, China, Olanda \u0219i India \u0219i-au unit for\u021bele pentru a desf\u0103\u0219ura un studiu clinic pe oameni privind eficacitatea NMN, ale c\u0103rui rezultate au fost publicate \u00een revista GeroScience \u00een decembrie 2022.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9735188\/\">studiu<\/a> se intitula: <em>Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu mononucleotid\u0103 de \u03b2-nicotinamid\u0103 (NMN) la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie: un studiu clinic randomizat, multicentric, dublu-orb, controlat cu placebo, cu grupuri paralele \u0219i dependent de doz\u0103<\/em>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acest studiu clinic a fost conceput pentru a evalua modul \u00een care suplimentarea cu NMN afecteaz\u0103 adul\u021bii s\u0103n\u0103to\u0219i afla\u021bi la v\u00e2rsta de mijloc. La studiu au participat \u00een total 80 de persoane cu v\u00e2rste cuprinse \u00eentre 40 \u0219i 65 de ani. Ace\u0219tia au fost repartiza\u021bi aleatoriu pentru a primi fie un placebo, fie o doz\u0103 oral\u0103 zilnic\u0103 de NMN \u2014 300 mg, 600 mg sau 900 mg \u2014 timp de 60 de zile.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul a urmat un protocol riguros: a fost un studiu randomizat, dublu-orb \u0219i controlat cu placebo, ceea ce \u00eenseamn\u0103 c\u0103 nici participan\u021bii, nici cercet\u0103torii nu \u0219tiau cine a primit NMN \u0219i cine a primit placebo pe durata studiului.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scopul principal al studiului a fost acela de a m\u0103sura varia\u021biile nivelurilor de NAD\u207a din s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen plus, cercet\u0103torii au evaluat mai multe rezultate secundare:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Siguran\u021ba \u0219i tolerabilitatea generale, pe baza analizelor de laborator \u0219i a efectelor secundare raportate<\/li>\n\n\n\n<li>Rezisten\u021ba fizic\u0103, m\u0103surat\u0103 prin intermediul unui test de mers pe jos de 6 minute<\/li>\n\n\n\n<li>V\u00e2rsta biologic\u0103, estimat\u0103 pe baza unor biomarkeri din s\u00e2nge<\/li>\n\n\n\n<li>Calitatea vie\u021bii, evaluat\u0103 prin intermediul unui chestionar<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-the-study-was-conducted\">Modul \u00een care a fost realizat studiul<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta a fost un studiu clinic randomizat, dublu-orb, controlat cu placebo, cu grupuri paralele, dependent de doz\u0103 \u0219i multicentric \u2014 un design metodologic solid, utilizat frecvent \u00een cercetarea clinic\u0103 pentru a asigura rezultate fiabile \u0219i impar\u021biale.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul a inclus 80 de adul\u021bi s\u0103n\u0103to\u0219i cu v\u00e2rste cuprinse \u00eentre 40 \u0219i 65 de ani. Participan\u021bii au fost repartiza\u021bi aleatoriu \u00een unul dintre cele patru grupuri: trei grupuri care au primit NMN (300 mg, 600 mg \u0219i 900 mg) \u0219i un grup placebo. Fiecare participant a luat capsulele care i-au fost alocate o dat\u0103 pe zi, timp de 60 de zile, \u00eenainte de micul dejun.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Capsulele cu NMN con\u021bineau 150 mg de mononucleotid\u0103 de \u03b2-nicotinamid\u0103 pur\u0103. Capsulele placebo aveau un aspect identic \u0219i con\u021bineau 150 mg de f\u0103in\u0103 de orez.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-group-overview\">Prezentare general\u0103 a grupului<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Grup<\/strong><\/th><th><strong>Aportul zilnic<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Grupul placebo<\/td><td>2\u20136 capsule cu placebo (fiecare con\u021bin\u00e2nd 150 mg de f\u0103in\u0103 de orez)<\/td><\/tr><tr><td>300 mg NMN Group<\/td><td>2 \u00d7 150 mg NMN<\/td><\/tr><tr><td>600 mg NMN Group<\/td><td>4 \u00d7 150 mg NMN<\/td><\/tr><tr><td>900 mg NMN Group<\/td><td>6 \u00d7 150 mg NMN<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">20 de participan\u021bi pe grup, adic\u0103 un total de 80 de participan\u021bi.<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-inclusion-and-exclusion-criteria\">Criterii de includere \u0219i de excludere<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Participan\u021bii eligibili au fost adul\u021bi s\u0103n\u0103to\u0219i care se \u00eencadrau \u00een intervalul de v\u00e2rst\u0103 specificat. Criteriile de excludere au inclus utilizarea suplimentelor pe baz\u0103 de NAD \u00eenainte de \u00eenceperea studiului, utilizarea actual\u0103 a statinelor, fumatul, consumul abuziv recent de droguri sau alcool sau participarea la alte studii clinice.<br>Femeile \u00eens\u0103rcinate sau care al\u0103pteaz\u0103 au fost excluse, iar toate participantele au fost supuse unui test de sarcin\u0103 din urin\u0103 \u00eenainte de \u00eenscriere.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-assessments-and-tests-conducted\">Evalu\u0103ri \u0219i teste efectuate<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Participan\u021bii au fost repartiza\u021bi aleatoriu \u00een unul dintre cele patru grupuri \u00een ziua 0. M\u0103sur\u0103torile ini\u021biale au fost efectuate \u00eenainte de \u00eenceperea oric\u0103rei supliment\u0103ri. Evalu\u0103rile de urm\u0103rire au fost efectuate \u00een ziua 30 \u0219i \u00een ziua 60 pentru a evalua at\u00e2t eficacitatea, c\u00e2t \u0219i siguran\u021ba.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Iat\u0103 o prezentare general\u0103 a evalu\u0103rilor efectuate:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nad-concentration-in-the-blood\">Concentra\u021bia de NAD\u207a \u00een s\u00e2nge<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Criteriul principal de evaluare a fost varia\u021bia nivelurilor de NAD\u207a din s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pentru cuantificarea NAD\u207a \u0219i NADH totale din ser s-a utilizat un test colorimetric validat.<br>\u00cen toate grupurile tratate cu NMN s-au observat cre\u0219teri semnificative, dependente de doz\u0103, ale nivelurilor de NAD, at\u00e2t \u00een compara\u021bie cu valorile ini\u021biale, c\u00e2t \u0219i cu cele din grupul placebo. Probele de s\u00e2nge au fost recoltate \u00een ziua 0, \u00een ziua 30 \u0219i \u00een ziua 60.<\/p>\n\n\n\n<div class=\"wp-block-group blog-definition\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">Test colorimetric<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un test colorimetric este o metod\u0103 de laborator care m\u0103soar\u0103 concentra\u021bia unei substan\u021be pe baza unei schimb\u0103ri de culoare. \u00cen acest studiu, testul a fost utilizat pentru a detecta concentra\u021biile totale de NAD\u207a \u0219i NADH \u00een serul sanguin. Cu c\u00e2t semnalul cromatic este mai intens, cu at\u00e2t concentra\u021bia este mai mare.<\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-safety-and-tolerability-of-nmn-supplementation\">Siguran\u021ba \u0219i tolerabilitatea supliment\u0103rii cu NMN<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Unul dintre obiectivele secundare a fost evaluarea siguran\u021bei \u0219i a tolerabilit\u0103\u021bii supliment\u0103rii cu NMN.<br>\u00cen acest scop, cercet\u0103torii au efectuat analize de s\u00e2nge \u0219i urin\u0103, precum \u0219i examin\u0103ri fizice pe toat\u0103 durata studiului. Toate evenimentele adverse au fost \u00eenregistrate \u0219i monitorizate. Tolerabilitatea a fost evaluat\u0103 \u0219i prin urm\u0103rirea faptului dac\u0103 participan\u021bii au finalizat studiul \u2014 \u0219i, \u00een mod remarcabil, nimeni din niciun grup nu a abandonat studiul.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-6-minute-walking-test\">Testul de mers pe jos de 6 minute<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Testul de mers pe jos de 6 minute a fost efectuat \u00een zilele 0, 30 \u0219i 60 pentru a evalua rezisten\u021ba.<br>Participan\u021bii au primit instruc\u021biuni s\u0103 parcurg\u0103 pe jos o distan\u021b\u0103 c\u00e2t mai mare \u00een decurs de 6 minute, iar distan\u021ba total\u0103 parcurs\u0103 a fost \u00eenregistrat\u0103. Acest lucru a constituit unul dintre indicatorii secundari de evaluare a efectului NMN asupra performan\u021bei fizice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cenrudit: <a href=\"https:\/\/staging.purovitalis.com\/ro\/nmn-imbunatateste-rezistenta-la-efort\/\">Studiu: Poate NMN s\u0103 te ajute s\u0103 ob\u021bii rezultate mai bune din antrenament?<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-the-biological-age-test\">Testul v\u00e2rstei biologice <\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">V\u00e2rsta biologic\u0103 a participan\u021bilor a fost estimat\u0103 cu ajutorul aplica\u021biei Aging.Ai 3.0 \u2013 un instrument digital care calculeaz\u0103 v\u00e2rsta aparent\u0103 a organismului pe baza rezultatelor analizelor de s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta utilizeaz\u0103 19 markeri sangvini obi\u0219nui\u021bi, printre care colesterolul, glicemia, proteinele, hemoleucograma, electroli\u021bii, precum \u0219i globulele ro\u0219ii \u0219i albe. M\u0103sur\u0103torile au fost efectuate la \u00eenceputul studiului (ziua 0) \u0219i la sf\u00e2r\u0219itul acestuia (ziua 60) pentru a vedea dac\u0103 NMN a avut vreun impact asupra semnelor de \u00eemb\u0103tr\u00e2nire ale organismului.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-homa-index\">Indicele HOMA<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Aceasta este valoarea care are o importan\u021b\u0103 deosebit\u0103 \u00een ceea ce prive\u0219te rezisten\u021ba la insulin\u0103. Ea indic\u0103 m\u0103sura \u00een care insulina \u00ee\u0219i poate exercita \u00eenc\u0103 ac\u021biunea \u00een organism. Valorile cuprinse \u00eentre 0,8 \u0219i 1,4 sunt considerate optime. Diabetul se instaleaz\u0103 la o valoare de aproximativ 2,5.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-sf-36-questionnaire\">Chestionarul SF-36<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Acest chestionar a fost conceput pentru a evalua calitatea vie\u021bii \u0219i starea general\u0103 de s\u0103n\u0103tate a participan\u021bilor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-summary-of-clinical-findings\">Rezumatul constat\u0103rilor clinice<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Pe baza evalu\u0103rilor prezentate mai sus, studiul clinic a reu\u0219it s\u0103 determine modul \u00een care diferite doze de suplimente cu NMN:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Influeaz\u0103 concentra\u021biile de NAD\u207a din s\u00e2nge<\/li>\n\n\n\n<li>Este tolerat de organismul uman<\/li>\n\n\n\n<li>Influeaz\u0103 rezisten\u021ba fizic\u0103<\/li>\n\n\n\n<li>Influeaz\u0103 v\u00e2rsta biologic\u0103<\/li>\n\n\n\n<li>Modific\u0103 rezisten\u021ba la insulin\u0103<\/li>\n\n\n\n<li>Are un impact asupra calit\u0103\u021bii vie\u021bii percepute \u0219i asupra st\u0103rii generale de s\u0103n\u0103tate<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1500\" height=\"1552\" src=\"https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide.webp\" alt=\"Eficacitatea placebo-ului \u0219i a celor trei grupuri tratate cu NMN , compara\u021bii \u00eentre cele trei grupuri tratate \u0219i grupul placebo, \u00eentre dozele de 600 mg \u0219i 300 mg, precum \u0219i \u00eentre dozele de 900 mg \u0219i 600 mg, privind modific\u0103rile eficacit\u0103\u021bii (\u0394medie \u00b1 SEM) de la momentul ini\u021bial p\u00e2n\u0103 \u00een ziua 30 \u0219i\/sau ziua 60.\" class=\"wp-image-1407\" srcset=\"https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide.webp 1500w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-600x621.webp 600w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-290x300.webp 290w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-990x1024.webp 990w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-768x795.webp 768w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-1485x1536.webp 1485w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-60x62.webp 60w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-110x114.webp 110w, https:\/\/staging.purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-32x32.webp 32w\" sizes=\"auto, (max-width: 1500px) 100vw, 1500px\" \/><figcaption class=\"wp-element-caption\"><span style=\"color: #333333; font-family: Georgia, Palatino, serif; font-size: 18px; font-weight: 400; background-color: #fcfcfc;\">Eficacitatea grupului placebo \u0219i a celor trei grupuri tratate cu NMN, compara\u021bii \u00eentre cele trei grupuri tratate \u0219i grupul placebo, \u00eentre doza de 600 mg \u0219i cea de 300 mg, \u0219i 900 mg fa\u021b\u0103 de 600 mg \u00een ceea ce prive\u0219te modific\u0103rile eficacit\u0103\u021bii (\u0394medie \u00b1 SEM) de la momentul ini\u021bial p\u00e2n\u0103 \u00een ziua 30 \u0219i\/sau ziua 60. Sursa imaginii: <a href=\"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-022-00705-1.pdf\">Springer<\/a>.<\/span><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nad-levels-increased-significantly-in-all-nmn-groups\">Nivelurile de NAD\u207a au crescut semnificativ \u00een toate grupurile tratate cu NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Toate cele trei doze de NMN (300, 600 \u0219i 900 mg\/zi) au condus la cre\u0219teri semnificative din punct de vedere statistic ale nivelurilor de NAD\u207a din s\u00e2nge, comparativ cu valorile ini\u021biale \u0219i cu placebo.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cre\u0219terea a fost dependent\u0103 de doz\u0103, dar diferen\u021ba dintre 600 mg \u0219i 900 mg a fost minim\u0103.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nmn-supplementation-appears-safe-and-well-tolerated\">Suplimentarea cu NMN pare s\u0103 fie sigur\u0103 \u0219i bine tolerat\u0103<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nu s-au constatat anomalii relevante din punct de vedere clinic \u00een niciunul dintre parametrii analizelor de s\u00e2nge sau de urin\u0103.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Au fost raportate \u00een total 9 evenimente adverse (EA): 6 \u00een grupul placebo, 1 \u00een grupul care a primit 300 mg de NMN \u0219i 2 \u00een grupul care a primit 600 mg.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niciunul dintre efectele adverse nu a fost considerat grav.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niciun eveniment advers nu a fost atribuit NMN.<br><\/li>\n\n\n\n<li>Niciun participant nu s-a retras din studiu.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-walking-distance-improved-in-nmn-groups\">Distan\u021ba parcurs\u0103 pe jos s-a \u00eembun\u0103t\u0103\u021bit \u00een grupurile tratate cu NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00cen grupul placebo nu s-a observat nicio schimbare semnificativ\u0103 a distan\u021bei parcurse pe jos.<\/li>\n\n\n\n<li>Toate grupurile tratate cu NMN au \u00eenregistrat \u00eembun\u0103t\u0103\u021biri semnificative la testul de mers pe jos de 6 minute p\u00e2n\u0103 \u00een ziua 60, comparativ cu grupul placebo.<\/li>\n\n\n\n<li>Grupul care a primit 600 mg a \u00eenregistrat rezultate mai bune dec\u00e2t cel care a primit 300 mg, \u00een timp ce nu s-a observat nicio diferen\u021b\u0103 semnificativ\u0103 \u00eentre grupurile care au primit 600 mg \u0219i cele care au primit 900 mg. <br><br> Poate vrei s\u0103 cite\u0219ti \u0219i: <a title=\"Suplimentele cu NMN \u00eembun\u0103t\u0103\u021besc func\u021biile musculare\" href=\"\/ro\/suplimentele-nmn-imbunatatesc-functiile-musculare\/\">Studiu: NMN ar putea \u00eembun\u0103t\u0103\u021bi func\u021bia muscular\u0103<\/a>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-biological-age-decreased-in-nmn-groups\">V\u00e2rsta biologic\u0103 a sc\u0103zut \u00een grupurile tratate cu NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00cen ziua 60, v\u00e2rsta biologic\u0103 a \u00eenregistrat o sc\u0103dere semnificativ\u0103 \u00een toate grupurile tratate cu NMN, comparativ cu valorile ini\u021biale.<\/li>\n\n\n\n<li>\u00cen schimb, grupul placebo a \u00eenregistrat o cre\u0219tere semnificativ\u0103 a v\u00e2rstei biologice.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-quality-of-life-scores-improved\">Scorurile privind calitatea vie\u021bii s-au \u00eembun\u0103t\u0103\u021bit<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Toate grupurile tratate cu NMN au \u00eenregistrat \u00eembun\u0103t\u0103\u021biri semnificative din punct de vedere statistic \u00een ceea ce prive\u0219te scorurile ob\u021binute la chestionarul de s\u0103n\u0103tate SF-36 p\u00e2n\u0103 \u00een ziua 60.<\/li>\n\n\n\n<li>Nu s-au constatat diferen\u021be semnificative \u00eentre grupurile tratate cu NMN.<\/li>\n\n\n\n<li>Grupul placebo nu a prezentat nicio \u00eembun\u0103t\u0103\u021bire semnificativ\u0103.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-understanding-the-effects-of-nmn\">\u00cen\u021belegerea efectelor NMN-ului<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Acest studiu clinic ofer\u0103 dovezi solide c\u0103 suplimentarea cu NMN este at\u00e2t sigur\u0103, c\u00e2t \u0219i eficient\u0103 pentru adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie. Prin \u00eembun\u0103t\u0103\u021biri semnificative ale nivelurilor de NAD\u207a, ale rezisten\u021bei, ale v\u00e2rstei biologice \u0219i ale calit\u0103\u021bii vie\u021bii, NMN demonstreaz\u0103 un poten\u021bial real ca parte a unei strategii de \u00eemb\u0103tr\u00e2nire s\u0103n\u0103toas\u0103.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dac\u0103 e\u0219ti curios s\u0103 afli cum po\u021bi integra NMN \u00een rutina ta zilnic\u0103, arunc\u0103 o privire la <a href=\"https:\/\/staging.purovitalis.com\/ro\/produse\/pulbere-nmn\/\">Suplimente cu NMN aici<\/a> \u2014 \u0219i sim\u021bi\u021bi diferen\u021ba pe care o poate face \u00een ceea ce prive\u0219te energia voastr\u0103 de zi cu zi.<\/p>\n\n\n\n<details class=\"wp-block-details blog-references is-layout-flow wp-block-details-is-layout-flow\"><summary>Referin\u021be <\/summary>\n<ol class=\"wp-block-list\">\n<li><strong>Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V.<\/strong> Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu mononucleotid\u0103 de \u03b2-nicotinamid\u0103 (NMN) la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie: un studiu clinic randomizat, multicentric, dublu-orb, controlat cu placebo, cu grupuri paralele \u0219i dependent de doz\u0103. <em>GeroScience<\/em>. 8 decembrie 2022;45(1):29\u201343. doi:10.1007\/s11357-022-00705-1. PMID: 36482258; PMCID: PMC9735188.<\/li>\n<\/ol>\n<\/details>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>table of contents For over a decade, NMN has been a focus of scientific interest due to its role in supporting cellular energy production and maintaining NAD\u207a levels \u2014 a key factor in metabolic health and aging.Animal studies have consistently shown promising effects: improved endurance, enhanced mitochondrial function, and signs of slowed biological aging. However, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":241796,"comment_status":"closed","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[177,168],"class_list":["post-170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-longevity","tag-nmn"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/comments?post=170"}],"version-history":[{"count":5,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170\/revisions"}],"predecessor-version":[{"id":241748,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170\/revisions\/241748"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/media\/241796"}],"wp:attachment":[{"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/media?parent=170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/categories?post=170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.purovitalis.com\/ro\/wp-json\/wp\/v2\/tags?post=170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}